Table 1 Search string used for each database

Scopus

#1: (TITLE-ABS-KEY(senescent) OR TITLE-ABS-KEY(senescence) OR TITLE-ABS-KEY(senescence, AND cellular) OR TITLE-ABS-KEY(cell AND senescence) OR TITLE-ABS-KEY(senescence, AND cell) OR TITLE-ABS-KEY(cell AND aging) OR TITLE-ABS-KEY(cellular AND ageing) OR TITLE-ABS-KEY(ageing, AND cellular) OR TITLE-ABS-KEY(aging, AND cell) OR TITLE-ABS-KEY(senescence, AND replicative) OR TITLE-ABS-KEY(cellular AND aging) OR TITLE-ABS-KEY(aging AND cellular) OR TITLE-ABS-KEY(replicative AND senescence) OR TITLE-ABS-KEY(cell AND ageing) OR TITLE-ABS-KEY(ageing, AND cell) OR TITLE-ABS-KEY(senescence-associated AND secretory AND phenotype) OR TITLE-ABS-KEY(phenotype, AND senescence-associated AND secretory) OR TITLE-ABS-KEY(secretory AND phenotype, AND senescence-associated) OR TITLE-ABS-KEY(senescence AND associated AND secretory AND phenotype) OR TITLE-ABS-KEY(sasp))

293

#2: (TITLE-ABS-KEY (hypoxia) OR TITLE-ABS-KEY (hypobaric) OR TITLE-ABS-KEY (normobaric) OR TITLE-ABS-KEY (high AND altitude))

#3: (TITLE-ABS-KEY (exercise) OR TITLE-ABS-KEY (training) OR TITLE-ABS-KEY (sport) OR TITLE-ABS-KEY (physical AND activity) OR TITLE-ABS-KEY (strength))

#1 AND #2 AND #3

Cochrane

#1: (senescent):ti,ab,kw OR (senescence):ti,ab,kw OR (senescence, cellular):ti,ab,kw OR (cell senescence):ti,ab,kw OR (senescence, cell):ti,ab,kw OR (cell ageing):ti,ab,kw OR (cellular ageing):ti,ab,kw OR (ageing cellular):ti,ab,kw OR (aging, cell):ti,ab,kw OR (senescence, replicative):ti,ab,kw OR (cellular aging):ti,ab,kw OR (aging, cellular):ti,ab,kw OR (replicative senescence):ti,ab,kw OR (cell ageing):ti,ab,kw OR (ageing, cell):ti,ab,kw OR (senescence-associated secretory phenotype):ti,ab,kw OR (phenotype, senescence-associated secretory):ti,ab,kw OR (secretory phenotype, senescence-associated):ti,ab,kw OR (senesence associated secretory phenotype):ti,ab,kw OR (SASP):ti,ab,kw

12

#2: (hypoxia):ti,ab,kw OR (hypobaric):ti,ab,kw OR (normobaric):ti,ab,kw OR (high altitude):ti,ab,kw

#3 (exercise):ti,ab,kw OR (training):ti,ab,kw OR (sport):ti,ab,kw OR (physical activity):ti,ab,kw OR (strength):ti,ab,kw

#1 AND #2 AND #3

PubMed

#1 (((((((((((((((((((senescent) OR (senescence)) OR (senescence, cellular)) OR (cell senescence)) OR (senescence, cell)) OR (cell aging)) OR (cellular ageing)) OR (ageing, cellular)) OR (aging, cell)) OR (senescence, replicative)) OR (cellular aging)) OR (aging, cellular)) OR (replicative senescence)) OR (cell ageing)) OR (ageing, cell)) OR (senescence-associated secretory phenotype)) OR (phenotype, senescence-associated secretory)) OR (secretory phenotype, senescence-Associated)) OR (senescence associated secretory phenotype)) OR (SASP)

572

#2 (((hypoxia) OR (hypobaric)) OR (normobaric)) OR (high altitude)

#3 ((((exercise) OR (training)) OR (sport)) OR (physical activity)) OR (strength)

#1 AND #2 AND #3

Web of Science

#1: (((((((((((((((((((((((((((((((((((((((TS=(senescent)) OR TI=(senescent)) OR TS=(senescence)) OR TI=(senescence)) OR TS=(senescence, cellular)) OR TI=(senescence, cellular)) OR TS=(cell senescence)) OR TI=(cell senescence)) OR TS=(senescence, cell)) OR TI=(senescence, cell)) OR TS=(cell aging)) OR TI=(cell aging)) OR TS=(cellular ageing)) OR TI=(cellular ageing)) OR TS=(ageing, cellular)) OR TI=(ageing, cellular)) OR TS=(aging, cell)) OR TI=(aging, cell)) OR TS=(senescence, replicative)) OR TI=(senescence, replicative)) OR TS=(cellular aging)) OR TI=(cellular aging)) OR TS=(aging, cellular)) OR TI=(aging, cellular)) OR TS=(replicative senescence)) OR TI=(replicative senescence)) OR TS=(cell ageing)) OR TI=(cell ageing)) OR TS=(ageing, cell)) OR TI=(ageing, cell)) OR TS=(senescence-associated secretory phenotype)) OR TI=(senescence-associated secretory phenotype)) OR TS=(phenotype, senescence-associated secretory)) OR TI=(phenotype, senescence-associated secretory)) OR TS=(secretory phenotype, senescence-associated)) OR TI=(secretory phenotype, senescence-associated)) OR TS=(senescence associated secretory phenotype)) OR TI=(senescence associated secretory phenotype)) OR TS=(SASP)) OR TI=(SASP)

1156

#2: (((((((TS=(hypoxia)) OR TI=(hypoxia)) OR TS=(hypobaric)) OR TI=(hypobaric)) OR TS=(normobaric)) OR TI=(normobaric)) OR TS=(high altitude)) OR TI=(high altitude)

#3: (((((((((TS=(exercise)) OR TI=(exercise)) OR TS=(training)) OR TI=(training)) OR TS=(sport)) OR TI=(sport)) OR TS=(physical activity)) OR TI=(physical activity)) OR TS=(strength)) OR TI=(strength)

#1 AND #2 AND #3