Table 2 Causality between genetically determined vigorous physical activity and 8 age-related diseases

Coronary heart disease

MR Egger

7

0.472

0.000

511.532

0.842

0.815

0.959

Weighted median

7

0.671

0.248

1.819

0.433

Inverse variance weighted

7

0.570

0.249

1.304

0.183

0.896

Weighted mode

7

0.729

0.188

2.832

0.664

Ischemic heart disease

MR Egger

7

0.036

0.000

26741.181

0.650

0.005

0.752

Weighted median

7

0.226

0.055

0.932

0.040

Inverse variance weighted

7

0.352

0.070

1.765

0.204

0.009

Weighted mode

7

0.293

0.046

1.876

0.243

Angina

MR Egger

7

0.837

0.595

1.177

0.353

0.164

0.498

Weighted median

7

0.940

0.900

0.983

0.006

Inverse variance weighted

7

0.949

0.913

0.987

0.009

0.191

Weighted mode

7

0.938

0.887

0.992

0.066

Alzheimer’s disease

MR Egger

6

0.003

0.000

1163635.996

0.600

0.063

0.644

Weighted median

6

0.535

0.072

3.991

0.542

Inverse variance weighted

6

0.479

0.063

3.640

0.477

0.092

Weighted mode

6

0.585

0.025

13.546

0.752

Hypertension

MR Egger

7

41.554

0.001

3025297.525

0.543

0.013

0.397

Weighted median

7

0.344

0.100

1.180

0.090

Inverse variance weighted

7

0.220

0.053

0.918

0.038

0.010

Weighted mode

7

0.400

0.094

1.710

0.263

 Type 2 diabetes

MR Egger

7

0.344

0.002

74.838

0.714

0.676

0.937

Weighted median

7

0.257

0.108

0.609

0.002

Inverse variance weighted

7

0.275

0.139

0.543

0.000

0.788

Weighted mode

7

0.226

0.055

0.925

0.084

High cholesterol

MR Egger

6

599.837

0.316

1137032.745

0.172

0.409

0.658

Weighted median

6

1.128

0.415

3.068

0.814

Inverse variance weighted

6

1.012

0.368

2.788

0.981

0.521

Weighted mode

6

1.056

0.225

4.942

0.948

Venous thromboembolism

MR Egger

7

0.961

0.789

1.170

0.706

0.602

0.838

Weighted median

7

0.983

0.954

1.013

0.271

Inverse variance weighted

7

0.982

0.959

1.005

0.117

0.719

Weighted mode

7

0.983

0.938

1.030

0.498