Table 3 Causality between genetically determined accelerometer-based physical activity and 8 age-related diseases

Coronary heart disease

MR Egger

8

1.196

0.964

1.483

0.154

0.036

0.196

Weighted median

8

0.995

0.951

1.042

0.842

Inverse variance weighted

8

1.024

0.971

1.079

0.382

0.011

Weighted mode

8

0.990

0.930

1.055

0.774

Ischemic heart disease

MR Egger

8

1.008

0.794

1.280

0.950

0.092

0.720

Weighted median

8

0.956

0.907

1.008

0.096

Inverse variance weighted

8

0.964

0.917

1.013

0.148

0.133

Weighted mode

8

0.956

0.885

1.032

0.288

Angina

MR Egger

8

1.004

0.999

1.009

0.190

0.645

0.071

Weighted median

8

0.999

0.997

1.000

0.098

Inverse variance weighted

8

0.998

0.997

1.000

0.013

0.250

Weighted mode

8

0.999

0.996

1.001

0.307

Alzheimer’s disease

MR Egger

6

1.119

0.642

1.948

0.712

0.000

0.709

Weighted median

6

0.996

0.905

1.095

0.929

Inverse variance weighted

6

1.002

0.882

1.139

0.970

0.001

Weighted mode

6

0.893

0.706

1.129

0.387

Hypertension

MR Egger

8

1.114

0.838

1.480

0.486

0.002

0.344

Weighted median

8

0.988

0.938

1.042

0.663

Inverse variance weighted

8

0.963

0.904

1.026

0.245

0.003

Weighted mode

8

0.994

0.924

1.070

0.883

 Type 2 diabetes

MR Egger

6

1.197

0.805

1.779

0.424

0.001

0.422

Weighted median

6

1.023

0.980

1.067

0.300

Inverse variance weighted

6

1.002

0.941

1.065

0.961

0.000

Weighted mode

6

1.040

0.983

1.101

0.226

High cholesterol

MR Egger

6

0.964

0.855

1.086

0.576

0.471

0.938

Weighted median

6

1.004

0.967

1.042

0.848

Inverse variance weighted

6

0.991

0.962

1.022

0.563

0.600

Weighted mode

6

1.018

0.957

1.082

0.602

Venous thromboembolism

MR Egger

8

1.000

0.992

1.007

0.913

0.000

0.938

Weighted median

8

0.999

0.998

1.001

0.372

Inverse variance weighted

8

0.999

0.998

1.001

0.368

0.001

Weighted mode

8

0.998

0.995

1.001

0.270