Combined influence of physical activity and C-reactive protein to albumin ratio on mortality among older cancer survivors in the United States: a prospective cohort study

Table 3 Association of CAR With All-Cause, Cancer Mortality Among US Cancer Survivors ≥ 40 years Stratified by PA Level

Mortality Outcome	Hazard Ratio (95% CI)^a
Mortality Outcome	PA ≥ 600 MET minutes/week (Physically Active)	PA < 600 MET minutes/week (Inactive/Insufficient Active)
All-Cause
CAR
Low	1 [reference]	1 [reference]
Medium	1.11 (0.86 ~ 1.44)	1.24 (1.03 ~ 1.49)
High	1.49 (1.14 ~ 1.95)	1.64 (1.37 ~ 1.97)
per SD increase	1.04 (0.98 to 1.11)	1.16 (1.10 ~ 1.22)
Cancer
CAR
Low	1 [reference]	1 [reference]
Medium	1.64 (1.01 ~ 2.67)	1.09 (0.75 ~ 1.57)
High	2.44 (1.48 ~ 4.02)	1.89 (1.33 ~ 2.68)
per SD increase	1.04 (0.93 to 1.17)	1.24 (1.15 ~ 1.34)

Abbreviations: CAR C-reactive protein-to-albumin ratio, US the United States, PA Physical Activity, CI Confidence interval, MET The metabolic equivalent
^a Adjusted for age (years), sex (male or female), race/ethnicity (non-Hispanic white, non-Hispanic black, Hispanic, and other), marital status (married or living with partner, widowed or divorced or separated or never married), education attainment (less than high school, high school graduate, above high school), family poverty ratio (< 1.30, 1.30–3.49, or ≥ 3.5), body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) (< 25, 25–29.9, and ≥ 30), smoking status (never, former, and current), alcohol use (never, former, and current), Healthy Eating Index-2015, hypertension (yes or no), history of diabetes (yes or no), history of CVD (yes or no)

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