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Table 5 Summary interpretation of the SHAP plots and variables relevant for categorization into decliners and non-decliners

From: Physical activity and the outcome of cognitive trajectory: a machine learning approach

 

Global cognition (MMSE)

Semantic verbal fluency (RWT_animals)

Executive function and visuo-spatial function (CDT)

Attention/executive function and processing speed (TMT)

Verbal short-term and working memory (DS)

Episodic verbal learning and memory (CVLT)

CG

Decline associated with older age, worse mobility (TUG), lower BMI, lower ADL performance (EADL), and fewer lower extremity strength and functionality (STS)

Decline associated with lower ADL performance (Barthel)

Decline associated with higher ADL performance (Barthel), CIRS, STA, and TUG scores. Non-decline linked to younger age

Decline associated with higher ADL performance (Barthel, PPT), lower extremity strength and function (STS)

Non-decline associated with higher mobility (TUG), BMI, and health status (CIRS)

No conclusive analysis for DS_for and DS_back

No conclusive analysis

IG

No decline associated with higher ADL performance (Barthel) higher mobility (TUG). Adherence showed no clear trend

Decline associated with lower ADL (EADL, Barthel). Non-decline associated with higher adherence and lower limb strength and functionality (STS)

Decline associated with lower adherence, lower mobility (TUG), and higher BMI,

Non-decline associated with higher adherence, higher mobility (TUG)

Decline associated with low ADL performance (Barthel Index

Non-decline associated with higher mobility (TUG) lower limb strength and functionality, and adherence

DS_for: Decline is associated with lower extremity strength and functionality (STS)

Non-decline associated with higher adherence, ADL performance (PPT), and higher extremity strength and functionality (STS)

DS_back: Weak trends

Decline associated with older age, lower ADL performance (Barthel) lower limb strength and function (STS)

Non-decline associated with higher adherence

  1. ADL Activities of daily living, BMI Body mass index, Barthel Barthel-questionnaire, CIRS Cumulative Illness Rating Scale, CDT Clock Drawing Test, CG Control group, CVLT California Verbal Learning Test, DS_back Digit Span Test backward, DS_for Digit Span Test forward, EADL Erlangen Test for Activities of Daily Living, IG Intervention group, MMSE Mini Mental State Examination, PPT Physical Performance Test, RWT_animals Regensburg Word Fluency Test subtest animals, STS Sit-to-stand test, TUG Timed-Up and Go test